Animal Models of Drug Addiction by Robert B. Stewart, Larry A. Grupp (auth.), Alan A. Boulton,

By Robert B. Stewart, Larry A. Grupp (auth.), Alan A. Boulton, Glen B. Baker, Peter H. Wu (eds.)

to the Animal versions Volumes This quantity describes animal types of drug dependancy. due to expanding public predicament over the moral therapy of animals in learn, we felt it incumbent upon us to incorporate this common preface on the way to point out why we predict extra study utilizing animals is critical. Animals may still simply be used whilst compatible possible choices are usually not on hand, and people can basically be experimented upon in critically proscribed situations. replacement methods utilizing cellphone or tissue tradition are insufficient in any versions requiring checks of behavioral switch or of advanced in vivo p- cesses. notwithstanding, whilst the misery, ache, or discomfort to the animals outweighs the predicted earnings for human welfare, the examine isn't moral and shouldn't be performed. it really is primary that every person researcher learn his/ her personal learn from a severe ethical viewpoint earlier than eng- ing in it, and think about the animals’ welfare in addition to the expected profits. additionally, as soon as a call to p- ceed with learn is made, it's the researcher’s accountability to make sure that the animals’ welfare is of top challenge when it comes to acceptable housing, feeding, and greatest aid of any uncomfortable or distressing results of the experimental conditions.

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M. (1976)Comparison between intravenous and intragastric alcohol self-administration. 4,91- 93. Staats J. (1966) The inbred mouse, in Biologyof the LaboratoryMouse,Green E. , McGraw Hill, New York, pp. l-11. Stewart R. B. and Grupp L. A. (1984) A simplified procedure for producing ethanol self-selection in rats. %258. Stewart R. B. and Grupp L. A. (1988) Conditioned place aversion mediated by orally self-administered ethanol in the rat: A consideration of blood ethanol levels. B&v. 32,331-371. Stewart R.

L. (1961) Production of polydipsia in normal rats by an intermittent food schedule. Science 133,195,196. Falk J. L. (1971) The nature and dete rminants of adjunctive behavior. Physiol. Behav. 6,577-5&X Falk J. L. (1983) Drug dependence: Myth or motive? Pharmucol. Bidem. Behav. 19,385-391. Falk J. L. and Samson H. H. (1976) Schedule-induced physical dependence on ethanol. Pharmacol. Rev. 27,449-464. Falk J. , Samson H. , and Winger G. (1972) Behavioral maintenance of high concentrations of blood ethanol and physical dependence in the rat.

Biochem. Behuv. 23,759-763. Deutsch J. A. and Hardy W. T. (1976) Ethanol tolerance in the rat measured by the untasted intake of alcohol. Behav. Biol. 17,379-389. 24 Stewart and Grupp Eriksson K. (1968) Genetic selection for voluntary alcohol consumption in the albino rat. Science 159,739-741. Eriksson K. (1969) Factors affecting voluntary alcohol consumption in the albino rat. Ann. Zml. Fennici. 6,227-2&S Falk J. L. (1961) Production of polydipsia in normal rats by an intermittent food schedule.

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