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6C). A minority compounds (10-20%) are essential, and Early Systems Biology and Prebiotic Networks 25 have a marked effect on the functional properties of the composomal network, as their removal significantly changes the assembly composition and/or reduces its growth rate. Fig. 6A, B respectively show the composition and the interaction network of a typical composome, highlighting the compounds essential for network stability. Surprisingly, essential compounds were not necessarily those with the highest concentration or highest connectivity within the network, suggesting non-trivial network properties.
Nature 407 (2000) 651-654 8. , Mason, S. , Barabasi, A. , Oltvai, Z. : Lethality and centrality in protein networks. Nature 411 (2001) 41-42 9. : The yeast protein interaction network evolves rapidly and contains few redundant duplicate genes. Mol. Biol. Evol. 18 (2001) 1283-1292 10. Wagner, A. ,Fell, D. : The small world inside large metabolic networks. Proc R Soc Lond B Biol Sci 268 (2001) 1803-1810 11. , Bader, J. , Hao, Y. , Ooi, C. , Stanyon, C. , Finley, R. , White, K. , Shimkets, R. , McKenna, M.
A parallel project, BioSpice was using a Model Deﬁnition Language that was currently identical to SBML Level 2 . Similarly the CellML project is an XML-based open standard for describing and exchanging models of cellular and subcellular processes . In our hands, theses approaches mostly focus on technological integration and deal with data exchange showing variations between formatting whereas the semantic approaches was dealing with a limited number of topics, all necessary for building workﬂow models but not expressive enough to account for the large variety of biological phenomena and experimental approaches to depict.