Advances in Genetics by M. Demerec (Eds.)

By M. Demerec (Eds.)

This quantity in a chain on genetics, emphasizes the range of genetic reviews. Articles conceal the filamentous fungus neurospora, biogenesis of yeast ribosomes, evolutionary genetics of fish, drosophila transposable parts and the dropophila gene zeste.

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1945b; Jukes and Dornbush, 1946). BIOCHEMICAL GENETICS OF NEUROSPORA 63 Isotope studies by Stetten (1941) and by du Vigneaud et al. (1946) indicate that in the rat choline is probably synthesized by means of a similar series of methylations. The mammal differs from Neurospora, however, in that the former is incapable of synthesizing labile methyl groups and requires a source of them, in the form of choline or methionine, in the diet.

The synthesis of lysine was shown to be controlled by a t least three, possibly six, loci. The most peculiar feature of these mutants is their specific inhibition by arginine. Growth is rapidly suppressed when the molecular ratio of arginine to lysine in the medium exceeds 1. Since wild-type is not affected by high concentrations of arginine, it is clear that the phenomenon is in some way related to the mutation. It is now known that inhibitions of this type are not uncommon among biochemical mutants.

Smear fixed with chloroform, then Feulgen reaction. Nuclear axial thread, n. 39. E. coli, strain B M . 24-hour culture in aerated nutrient broth at 37°C. Giemsa staining. Various aspects of cells. Fro. 40. Same as Fig. 39; division figures of nuclear elements. 41-43. E. coli, strain B/r. 42-hour culture in nonaerated nutrient broth at 37°C. Giemsa staining. 41. Three rods having two to four nuclear elements (n), one dividing. 42. Two rods. At left, dividing rod with four dividing nuclear elements (V-shaped).

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